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InSolution JNK Inhibitor II-Calbiochem
| 产品编号： | 4084078 |
| 规格： | The InSolution |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H8N2O |
| Molecular weight | 220.23 |
| General description【一般描述】 | A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3 Primary Target JNK 1, JNK 2, JNK 3 Product competes with ATP. Reversible: yes |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO. |
| Reconstitution【重悬】 | Following initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage. |
| Other Notes【其他说明】 | Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA98, 13681. Han, Z., et al. 2001. J. Clin. Invest.108, 73. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| color【颜色】 | yellow-brown |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
