InSolution eIF4E/eIF4G Interaction Inhibitor, 4EGI-1-CAS 315706-13-9-Calbiochem

C₁₈H₁₂Cl₂N₄O₄S

451.28

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; K_D = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-x_L in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC₅₀ ~25 µM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.

Cell permeable: yes
Reversible: yes
Primary Target
eIF4E

Toxicity: Irritant (B)

A 25 mM (5 mg/443 µL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517)

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Gkogkas, C.G., et al. 2012. Nature493, 371.
Moerke, N. J., et al. 2007. Cell128, 257.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

≥95% (sum of two isomers, HPLC)

100

liquid

25 μM K_i

Calbiochem^®

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

dry ice

−70℃

5 mg in Glass bottle
Packaged under inert gas

12 - Non Combustible Liquids

WGK 2