InSolution Casein Kinase II Inhibitor III, TBCA-CAS 934358-00-6-Calbiochem

C₉H₄Br₄O₂

463.74

MFCD20921901

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (>Cat. No. 218697 and >Cat. No. 218708) and DMAT (Cat. No. 218699 and Cat. No. 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.

Cell permeable: yes
Primary Target
CKII
Reversible: yes

Toxicity: Irritant (B)

A 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Pagano, M.A., et al. 2006. Chembiochem,8, 129.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥90% (HPLC)

liquid

Calbiochem^®

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

dry ice

−70℃

OC(/C=C/C1=CC(Br)=C(Br)C(Br)=C1Br)=O

5 mg in Glass bottle
Packaged under inert gas

10 - Combustible liquids

WGK 1

188.6 °F - (refers to pure substance)

87 ℃ - (refers to pure substance)