Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴-Calbiochem

C₆₁H₆₅N₁₅O₆

1104.27

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC₅₀ = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca²⁺]_i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Aβ₄₂ peptide-induced superoxide generation and prevents its internalization in human macrophages.
A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC₅₀ = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca²⁺]_i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ₄₂ peptide-induced superoxide generation and prevents its internalization in human macrophages.

Product does not compete with ATP.
Primary Target
Formyl Peptide Receptor-Like 1 (FPRL1)
Target IC₅₀: 230 nM for FPRL1 Agonist
Reversible: no
Cell permeable: no

Toxicity: Standard Handling (A)

H-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂

Supplied as a trifluoroacetate salt.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Bae, Y.S., et al. 2004. J. Immunol.173, 607.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

lyophilized solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white

DMSO: 5 mg/mL

ambient

2-8℃

5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1