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Formyl Peptide Receptor-Like 1 Agonist, WKYMVm-Calbiochem
| 产品编号： | 4084047 |
| 规格： | The Formyl Peptide Receptor-Like 1 Agonist, WKYMVm controls the biological activity of Formyl Peptide Receptor-Like 1. This small molecule/inhibitor is primarily used for Activators/Inducers applications. |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Formyl Peptide Receptor-Like 1 Agonist, WKYMVm-Calbiochem
H2N-WKYMV- D-M-CONH2, FPRL1 Agonist, WKYMVm
H2N-WKYMV-D-M-CONH2, FPRL1 Agonist, WKYMVm
基本信息
| Empirical Formula【经验(实验)分子式】 | C41H61N9O7S2 |
| Molecular weight | 856.11 |
| General description【一般描述】 | A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca2+] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue. A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). More poteut than fmlp at inducing neutrophil chemotaxis, neutrophil complement receptor 3. Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM) and in U937 and HL60 cells. Has no effect inositide phosphate synthecs in a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Radioiodinatable at the tyrosine residue. |
| Biochem/physiol Actions【生化/生理作用】 | EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells Product does not compete with ATP. Reversible: no Primary Target Formyl Peptide Receptor-Like 1 Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | H-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂ |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Bae, Y.S., et al. 2004. J. Immunol.173, 607. Bae, Y.S., et al. 2003. Mol. Pharmacol.64, 841. Le, Y., et al. 1999. J. Immunol.163, 6777. Seo, J.K., et al. 1997. J. Immunol.158, 1895. Baek, S.H., et al. 1996. J. Biol. Chem.271, 8170. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | lyophilized |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
