TrkB Antagonist, ANA-12-CAS 219766-25-3-Calbiochem

C₂₂H₂₁N₃O₃S

407.49

MFCD00117444

A cell-permeable thiophene carboxymide derived compound that acts as a direct and selective antagonist of TrkB receptor. Binds to the high affinity site on the extracellular domain of TrkB in a dose-dependent manner (K_d = 10 nM) exhibiting much reduced binding to the low affinity site (K_d =12 µM) indicating that it does not compete with BDNF for the same binding site. Does not affect TrkA or TrkC receptors. Shown to permeate the blood-brain barrier, however, its antagonistic effects are not uniform throughout the brain. Does not affect the survivability of neurons. Reduces anxiety and depression related behavior in mice.

Primary Target
TrkB

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Cazorla, M., et al. 2011. J. Clin. Invest.121,1846.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

10 nM K_i

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 25 mg/mL

2-8℃

Packaged under inert gas

GHS07

Warning

H302

P264 - P270 - P301 + P312 - P501

Acute Tox. 4 Oral

11 - Combustible Solids

WGK 3