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Anti-TOM1L1 antibody produced in mouse
产品编号: | 3402034 |
规格: | purified immunoglobulin, buffered aqueous solution |
包装规格: | 50 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-TOM1L1 antibody produced in mouse
SRCASM
OK/KNS-CL.3
基本信息
NACRES | NA.41 |
General description【一般描述】 | Mouse polyclonal antibody raised against a full-length human TOM1L1 protein. The gene TOM1L1 (target of myb1 like 1 membrane trafficking) is mapped to human chromosome 17q23.(5) The protein has a VHS (Vps27p/Hrs/Stam) domain at the N-terminal, a GAT (GGA (Golgi-localizing, ?-adaptin ear domain homology, ADP-ribosylation factor (Arf)-binding protein and Tom) domain at the center and interaction motifs at the C-terminal.1,2 |
Immunogen【免疫原】 | TOM1L1 (AAH29396.1, 1 a.a. ~ 346 a.a) full-length human protein. Sequence MAFGKSHRDPYATSVGHLIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLTLSLIDMCVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEVYLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSENHEDIELLQKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRILEQNKNQKEATNTTSEPSAPSQDLLDLSPSPRMPRATLGELNTMNNQLSGLSK |
Biochem/physiol Actions【生化/生理作用】 | TOM1L1 (target of myb1 like 1 membrane trafficking) is an adaptor protein, which is involved in vesicular trafficking as well as intracellular signaling. It negatively controls the mitogenic and transforming functions in fibroblasts by working as a substrate for SRC (tyrosine protein kinase).1,2 It is involved in EGF (epidermal growth factor)-mediated internalization of EGF receptor.4 TOM1L1 is downregulated in cutaneous squamous cell carcinoma and esophageal squamous cell carcinoma.3 |
Physical form【外形】 | Solution in phosphate buffered saline, pH 7.4 |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen ~38.7 kDa |
species reactivity | human |
technique(s) | western blot: 1 μg/mL |
NCBI accession no.【NCBI登记号】 | BC029396.1 |
UniProt accession no.【UniProt登记号】 | O75674 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... TOM1L1(10040) |
安全信息
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 1 |