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Anti-Lin28 antibody produced in rabbit

产品编号:3373488
规格:affinity isolated antibody
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3373488100 μG4610
产品别名

Anti-Lin28 antibody produced in rabbit

Anti-CSDD1

Anti-LIN28A

Anti-LIN-28

Anti-ZCCHC1

基本信息
NACRES
NA.41
General description【一般描述】
The Lin28 (lin-28 homolog A) gene encodes RNA-binding protein, and is located on human chromosome 1p36.

The antibody detects endogenous levels of total Lin28 protein.
Immunogen【免疫原】
Peptide sequence around aa. 1-5 (M-G-S-V-S), according to the protein NP_078950.1
Biochem/physiol Actions【生化/生理作用】
The Lin28 (lin-28 homolog A) protein participates in several biological processes like development, reprogramming, differentiation, pluripotency and glucose metabolism.{19, 20} It plays an important role in immunity.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
~26 kDa
species reactivity
mouse, human, rat
concentration【浓度】
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype【同位素/亚型】
IgG
immunogen sequence【免疫原序列】
(M-G-S-V-S)
NCBI accession no.【NCBI登记号】
NM_024674.4
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... Lin28(79727)
产品说明
Target description【目标描述】
Acts as a ′translational enhancer′, driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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