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Anti-CBLB antibody produced in rabbit
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产品编号: | 3351176 |
规格: | Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution |
包装规格: | 100 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-CBLB antibody produced in rabbit
Anti-Casitas B-lineage lymphoma proto-oncogene b
Anti-RING finger protein 56
Anti-Signal transduction protein CBL-B
Anti-SH3-binding protein CBL-B
Anti-E3 ubiquitin-protein ligase CBL-B
基本信息
Human Protein Atlas Number【人类蛋白质图谱编号】 | HPA018327 Human Protein Atlas characterization data |
General description【一般描述】 | The gene casitas B-lineage lymphoma proto-oncogene b (CBLB) is mapped to human chromosome 3q13.11. It belongs to CBL family of ubiquitin ligases. |
Immunogen【免疫原】 | E3 ubiquitin-protein ligase CBL-B recombinant protein epitope signature tag (PrEST) |
Application【应用】 | All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige. |
Biochem/physiol Actions【生化/生理作用】 | Casitas B-lineage lymphoma proto-oncogene b (CBLB) is phosphorylated upon T cell receptor (TCR) stimulation and is involved in TCR-mediated intracellular signaling pathways. Similarly, phosphorylated CBLB is recruited to epidermal growth factor receptor (EGFR) upon EGF stimulation and inhibits EGF-induced cell growth. CBLB interacts with CIN85 (SH3 domain-containing kinase-binding protein 1) and together they regulate EGF receptor endocytosis and down-regulation of the activated receptor. CBLB participates in controlling T-cell activation thresholds by negative regulation of Vav, a GDP/GTP exchange factor. The molecular mechanism involves CBLB-mediated degradation of p85 regulatory subunit of phosphatidylinositol 3-kinase, an upstream regulator of Vav. CBLB is associated with an autoimmune disease of the central nervous system, multiple sclerosis. |
Features and Benefits【特点和优势】 | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways:
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Linkage【联系】 | Corresponding Antigen APREST73956. |
Physical form【外形】 | Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide |
Legal Information【法律信息】 | Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC |
产品性质
biological source【生物来源】 | rabbit |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
product line【产品线】 | Prestige Antibodies® Powered by Atlas Antibodies |
form【形式】 | buffered aqueous glycerol solution |
species reactivity | human |
packaging【包装】 | antibody small pack of 25 μL |
technique(s) | immunohistochemistry: 1:50- 1:200 |
immunogen sequence【免疫原序列】 | PPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKP |
UniProt accession no.【UniProt登记号】 | Q13191 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... CBLB(868) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |