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6-硫-2′-脱氧鸟苷
6-Thio-2′-Deoxyguanosine
产品别名
789-61-7
6-硫-2′-脱氧鸟苷
6-Thio-2′-Deoxyguanosine
2′-Deoxythioguanosine
NSC 71261
2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione (7CI,8CI)
2′-Deoxy-6-thioguanosine
2′-Ddeoxy-6-thio-guanosine
2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercaptopurine
6-Thio-dG
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H13N5O3S |
| Molecular weight | 283.31 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825770 |
| NACRES | NA.77 |
| Application【应用】 | 6-Thio-2′-Deoxyguanosine has been used in secreted luciferase enzyme activity in tonsillar cancer cells. |
| Biochem/physiol Actions【生化/生理作用】 | 6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. 6-Thio-2′-deoxyguanosine induces telomere dysfunction and rapid cell death in cancer cells, while spearing telomerase-negative cells. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to brown |
| solubility【溶解性】 | DMSO: 5 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | S=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)O3)C=N2)N=C(N)N1 |
| InChI | 1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5-,6-/m1/s1 |
| InChI key | SCVJRXQHFJXZFZ-HSUXUTPPSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
