甲氧苄啶 乳酸盐

C₁₄H₁₈N₄O₃ · C₃H₆O₃

380.40

245-533-1

MFCD00171722

329826610

NA.85

Chemical structure: pyrimidine

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

Keep container tightly closed in a dry and well-ventilated place.

200

≥98%

powder

(Keep container tightly closed in a dry and well-ventilated place.)

white

H₂O: soluble 20 mg/mL

DNA synthesis | interferes
enzyme | inhibits

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

2-8℃

CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)

IIZVTUWSIKTFKO-UHFFFAOYSA-N

250 mg in glass bottle

GHS06,GHS08

Danger

H301 - H361d

P202 - P264 - P270 - P280 - P301 + P310 - P405

Acute Tox. 3 Oral - Repr. 2

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3

Eyeshields, Gloves, type N95 (US)