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MJ33 锂盐

MJ33 lithium salt
产品编号:3139096
规格:powder, ≥90% (NMR)
CAS NO:199106-13-3
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
31390965 MG2950
产品别名

199106-13-3

MJ33 锂盐

MJ33 lithium salt

1-Hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol lithium

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C22H43F3O6PLi
Molecular weight
498.48
MDL number
MFCD03787978
PubChem Substance ID【PubChem化学物质编号】
24278549
NACRES
NA.77
Application【应用】
MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor:
  • to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates
  • to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxia
  • to study its potential use as a therapeutic agent

Biochem/physiol Actions【生化/生理作用】
MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate.
Novel, active site directed, specific, competitive and reversible inhibitor of phospholipase A2 (PLA2).
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥90% (NMR)
form【形式】
powder
color【颜色】
white to beige
solubility【溶解性】
H2O: ≥5 mg/mL (warmed at 60 ℃)
storage temp.【储存温度】
2-8℃
SMILES string
CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(OC)([O-])=O.[Li+]
InChI
1S/C22H44F3O6P.Li/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29-18-21(31-32(26,27)28-2)19-30-20-22(23,24)25;/h21H,3-20H2,1-2H3,(H,26,27);/q;+1/p-1
InChI key
GDLMLQJISATCEL-UHFFFAOYSA-M
packaging【包装】
5 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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