TNF-α Antagonist III, R-7050-CAS 303997-35-5-Calbiochem

C₁₆H₈ClF₃N₄S

380.77

MFCD00140737

A cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC₅₀ = 0.631 and 1.45 µM, respectively) in A549 cells.

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Gururaja, T.L., et al. 2007. Chem. Biol.14, 1105.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

powder

Calbiochem^®

OK to freeze
protect from light

light yellow

DMSO: 5 mg/mL

ambient

2-8℃

10 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3