MMP Inhibitor I-Calbiochem

C₂₃H₃₄N₆O₆

490.55

A tetrapeptidyl hydroxamic acid that inhibits MMP-1 and MMP-8 (IC₅₀ = 1.0 µM), MMP-9 (IC₅₀ = 30 µM) and MMP-3 (IC₅₀ = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. Nos. 53702 or 537088) or human granulocyte elastase.
A tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC₅₀ = 1 µM), granulocyte gelatinase (MMP-9; IC₅₀ = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC₅₀ = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. No. 53702) or human neutrophil elastase.

Primary Target
MMP-1, MMP-8
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Standard Handling (A)

4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Hagemamn, T., et al. 2004. Carcinogenesis25, 1543.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

1 μM IC₅₀

Calbiochem^®

OK to freeze

white

water: 1 mg/mL

ambient

−20℃

10 mg in Plastic ampoule

11 - Combustible Solids

WGK 1