D-erythro-Sphingosine, Free Base, High Purity-CAS 123-78-4-Calbiochem

C₁₈H₃₇NO₂

299.49

MFCD00036751

Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. A potent, cell-permeable, reversible, and selective inhibitor of protein kinase C (PKC; IC₅₀ = 2.8 µM) and insulin receptor tyrosine kinase. PKC inhibition is competitive with respect to diacylglycerol, phorbol dibutyrate, and Ca²⁺. Does not affect the activity of myosin light chain kinase and protein kinase A. Induces apoptosis in human leukemia HL-60 cells. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.

Target IC₅₀: 2.8 µM against PKC
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
PKC

Toxicity: Irritant (B)

Following reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (TLC)

solid

Calbiochem^®

OK to freeze

white

chloroform: 1 mg/mL
methanol: 1 mg/mL
DMSO: 10 mg/mL

ambient

−20℃

1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1

WWUZIQQURGPMPG-KRWOKUGFSA-N

10 mg in Plastic ampoule

11 - Combustible Solids

WGK 3