Vatalanib dihydrochloride

产品编号：

4141339

规格：	≥98% (HPLC)

CAS NO：

包装规格：

10 MG，50 MG

产品类别：

进口试剂

品牌：	Sigma-Aldrich

优惠价：

产品别名

212141-51-0

Vatalanib dihydrochloride

1-(4-Chloroanilino)-4-(4-pyridylmethyl)phthalazine dihydrochloride

CGP 79787D dihydrochloride

N-(4-Chloroanilino)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride

ZK-222584 dihydrochloride

PTK 787 dihydrochloride

ZK222584 dihydrochloride

PTK787 dihydrochloride

ZK 222584 dihydrochloride

CGP 79787 dihydrochloride

结构式

基本信息

Empirical Formula【经验(实验)分子式】	C₂₀H₁₅ClN₄ · 2HCl
Molecular weight	419.73
MDL number	MFCD08458963
Biochem/physiol Actions【生化/生理作用】	Vatalanib (PTK787, ZK 222584, CGP 79787D, CGP 79787 succinate) is an orally active anilinophthalazine derivative that exerts its anti-angiogenic efficacy by targeting receptor tyrosine kinase (RTK) VEGFR (VEGFR1/2 IC50 = 54/39 nM; IC50 ∼30 nM against 100 ng/mL VEGF-C-induced VEGFR3 autophosphorylation in MEVCs) and, to a less extent, PDGFRβ, c-kit, c-fms (IC50 = 364, 600, 567 nM, respectively) in an ATP-competitive manner with much reduced or no potency toward >90 other kinases. Typical dosing ranges: 0.1-10 μM in cultures, 5 nM-200 μM (zebrafish) and 30-100 mg/kg (mice & rats via po. or ip) in vivo.

产品性质

Assay【测定】	≥98% (HPLC)
form【形式】	powder
storage condition【储存条件】	desiccated
color【颜色】	white to beige
solubility【溶解性】	H₂O: 2 mg/mL, clear
storage temp.【储存温度】	2-8℃
SMILES string	ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42

安全信息

Storage Class Code【储存分类代码】	13 - Non Combustible Solids
WGK	WGK 3

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