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Rb (48-378), GST tagged human
| 产品编号： | 4140250 |
| 规格： | recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
| CAS NO： | 1025177-56-3 |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
1025177-56-3
Rb (48-378), GST tagged human
OSRC
RB1
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥70% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| mol wt【分子量】 | ~62 kDa |
| NCBI accession no.【NCBI登记号】 | NM_000321 |
| application(s) | cell analysis |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... RB1(5925) |
基本信息
| General description【一般描述】 | The gene encoding RB transcriptional corepressor 1 (RB1) is a tumor suppressor gene localized on human chromosome 13q14.2. |
| Biochem/physiol Actions【生化/生理作用】 | RB transcriptional corepressor 1 (RB1) modulates the cell cycle. It acts as a repressor of transcription mediated by E2 factor (E2F) and influences transcriptional silencing. RB1 modulates mitochondrial activities and has a role in the organization of heterochromatin. Mutations in the gene encoding this protein have been associated with childhood retinoblastoma. |
| Physical form【外形】 | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Preparation Note【制备说明】 | after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
