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Anti-MART-1 antibody produced in rabbit
| 产品编号： | 4110051 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-MART-1 antibody produced in rabbit
Anti-MART1
Anti-Melanoma antigen recognized by T-cells 1
Anti-MART-1
Anti-MLANA
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Anti-MART-1 is produced in rabbit using a synthetic peptide corresponding to a sequence from the internal region of human MART-1 protein, conjugated to keyhole limpet hemocyanin (KLH). Melanoma antigen recognized by T-cells 1 (MART-1), also known as melan-A antigen, LB39-AA or antigen SK29-AA, is a type III signal-anchor protein that is localized mainly to the endoplasmic reticulum, the trans-Golgi network and melanosomes. MART-1 protein is expressed specifically in normal skin, retina, melanocyte cell lines and melanomas. It is a melanoma antigen recognized by T-cells and belongs to the melanocyte differentiation markers. |
| Immunogen【免疫原】 | synthetic peptide corresponding to a sequence from the internal region of human MART-1 protein, conjugated to KLH |
| Application【应用】 | Anti-MART-1 antibody produced in rabbit has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | Melanoma antigen recognized by T-cells 1 (MART-1) is specifically recognized by human leukocyte antigen (HLA-A2) restricted tumor-infiltrating T lymphocytes (TIL-1) in melanoma patients and is suggested to be involved in tumor progression. It is also involved in pigmentation process and is suggested as a candidate marker for albinism. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~13 kDa |
| species reactivity | human |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | immunoblotting: 2-4 μg/mL using human melanoma SK-Mel-28 cell line extract immunofluorescence: 0.25-0.5 μg/mL using human melanoma SK-Mel-28 cell line immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human melanoma sections |
| UniProt accession no.【UniProt登记号】 | Q16655 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MART-1(2315) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
