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3β-hydroxy-7-oxo-5-cholestenoic acid
| 产品编号： | 4095670 |
| 规格： | (25R)-cholest-5-en-26-oic acid, 3β-hydroxy-7-oxo, powder |
| CAS NO： | 1246298-64-5 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Avanti |
| 优惠价： | 立即咨询 |
产品别名
1246298-64-5
3β-hydroxy-7-oxo-5-cholestenoic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H42O4 |
| Molecular weight | 430.62 |
| NACRES | NA.25 |
| General description【一般描述】 | Cholestenoic acids are cholesterol metabolic intermediates and precursors to bile acids. 3β-hydroxy-7-oxo-5-cholestenoic acid is synthesized from 7β-hydroxycholesterol. The enzymes for synthesis of cholestenoic acids are majorly present in the central nervous system (CNS) of mammals. 3β-hydroxy-7-oxo-5-cholestenoic acid (3βH,7O-CA) is also synthesized from 26-hydroxy-7-oxocholesterol by the action of the enzyme cytochrome P450 family 27 subfamily A member 1 sterol 27-hydroxylase (CYP27A1). |
| Biochem/physiol Actions【生化/生理作用】 | 3β-hydroxy-7-oxocholest-5-en-26-oic acid (3βH,7O-CA) acts as a ligand for liver X receptors (LXR) and activates them at micromolar concentration. 3βH,7O-CA favors the islet-1+ cells synthesis and islet-1–GFP expression. 3βH,7O-CA also mediates oculomotor neurons maturation and its conversion to 3β,7β-dihydroxycholest-5-en-(25S)26-oic acid (3β,7β-diHCA) is catalyzed by the enzyme hydroxysteroid 11-β dehydrogenase. |
产品性质
| Assay【测定】 | >99% (TLC) |
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 700026P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (700026P-5mg) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
