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25-hydroxycholesterol-3-sulfate
| 产品编号： | 4095423 |
| 规格： | 25-hydroxycholesterol-3-sulfate (sodium salt), powder |
| CAS NO： | 884905-07-1 |
| 包装规格： | 5 MG，10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Avanti |
| 优惠价： | 立即咨询 |
产品别名
884905-07-1
25-hydroxycholesterol-3-sulfate
5-cholesten-3beta, 25-diol 3-sulfate; 25HC3S
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H45NaO5S |
| Molecular weight | 504.70 |
| NACRES | NA.25 |
| General description【一般描述】 | 25-hydroxycholesterol-3-sulfate (25OHC3S) is a nuclear oxysterol. It accumulates in hepatocyte nuclei upon steroidogenic acute regulatory protein (STARD1) overexpression. |
| Application【应用】 | 25-hydroxycholesterol-3-sulfate has been used to induce anti-inflammatory responses and understand its effect on lymphocyte migration. It has also been used as an oxysterol sulfate standard in mass spectroscopy and liquid chromatography methods. |
| Biochem/physiol Actions【生化/生理作用】 | 25-hydroxycholesterol-3-sulfate (25OHC3S) is involved in lipid homeostasis in liver and is a lipid metabolism regulator. 25OHC3S acts on liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) and inhibits cholesterol synthesis by downregulating enzymes of the biosynthesis pathway in hepatocytes and macrophages. It also acts an agonist for peroxisome proliferator-activated receptor γ (PPAR-γ) and modulates the nuclear factor κ-light-chain-enhancer (NF-κB) based inflammatory response. 25OHC3S modulates tumor necrosis factor α (TNFα)-induced inflammatory response in hepatocytes. |
产品性质
| Assay【测定】 | >99% (TLC) |
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 700017P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | [H][C@@]12[C@]([C@](CC[C@H](OS(=O)([O-])=O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)(O)C.[Na+] |
| packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (700017P-10mg) 5 mL Amber Glass Screw Cap Vial (700017P-5mg) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
