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Angeli′s Salt-CAS 13826-64-7-Calbiochem
| 产品编号： | 4095178 |
| 规格： | A nitroxyl anion (NO-) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. |
| CAS NO： | 13826-64-7 |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
13826-64-7
Angeli′s Salt-CAS 13826-64-7-Calbiochem
Angeli’s Salt-CAS 13826-64-7-Calbiochem
Sodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate
基本信息
| Empirical Formula【经验(实验)分子式】 | N2O3 · 2Na |
| Molecular weight | 121.99 |
| General description【一般描述】 | A nitroxyl anion (NO–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0. A nitroxyl anion (NO-) donor that spontaneously, in the presence of oxygen and Cu2+ and Fe3+, dissociates in a pH-dependent, first-order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) of NO release = 2.3 min. (in 100 mM phosphate buffer, pH 7.4 at 37°C). Induces relaxation of norepinephrine-constricted rabbit aorta (EC50 = 590 nM). Angeli′s Salt produces nitroxyl anion (NO-) that can be converted to NO in the presence of heme. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target Nitroxyl anion (NO-) donor Product does not compete with ATP. Reversible: no Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution in alkaline solution, store at -20°C. This product is stable for 6 months as supplied. Alkaline stock solutions are stable for up to 24 h at -20°C. Unstable in acidic or neutral pH buffers. |
| Other Notes【其他说明】 | Miranda, K.M., et al. 2001. J. Biol. Chem.276, 1720. Hrinczenko, B.W., et al. 2000. Br. J. Haematol.110, 412. Nelli, S., et al. 2000. Br. J. Pharmacol.131, 356. Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA96, 14617. Keefer, L.K., et al. 1996. Methods Enzymol.268, 281. Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun.196, 707. Maragos, C.M., et al. 1991. J. Med. Chem.34, 3242. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥99% |
| form【形式】 | crystalline solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| solubility【溶解性】 | alkaline solution: soluble (0.01 M NaOH) |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
