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Insulin-like Growth Factor-I Receptor human
| 产品编号： | 4094044 |
| 规格： | ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Insulin-like Growth Factor-I Receptor human
IGF-I Receptor
基本信息
| MDL number | MFCD01323726 |
| NACRES | NA.32 |
| General description【一般描述】 | IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies. |
| Application【应用】 | Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides. |
| Biochem/physiol Actions【生化/生理作用】 | IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity. |
| Physical form【外形】 | Lyophilized from a 0.2 μm solution in phosphate buffered saline. |
| Analysis Note【分析说明】 | The biological activity is measured by its ability to bind human IGF-I in a functional ELISA assay. As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in NSO cells |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| mol wt【分子量】 | α-chain ~120 & 150 kDa β subunit ~46 & 50 kDa |
| packaging【包装】 | pkg of 50 μg |
| impurities【杂质】 | endotoxin, tested |
| UniProt accession no.【UniProt登记号】 | P08069 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IGF1R(3480) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
