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Heregulin-β, EGF Domain human
| 产品编号： | 4093805 |
| 规格： | ≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Heregulin-β, EGF Domain human
HRG-β
基本信息
| MDL number | MFCD01867052 |
| NACRES | NA.32 |
| General description【一般描述】 | Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin. |
| Biochem/physiol Actions【生化/生理作用】 | Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways. |
| Physical form【外形】 | Solution in phosphate buffered saline containing 30% glycerol. |
| Analysis Note【分析说明】 | Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor. The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥80% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| mol wt【分子量】 | 185 kDa |
| packaging【包装】 | pkg of 100 μg |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| UniProt accession no.【UniProt登记号】 | Q02297 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... NRG1(3084) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
