Protein Synthesis Initiation Inhibitor, NSC 119889-Calbiochem

C₂₀H₈Br₄O₅

647.89

A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5′-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).

Cell permeable: yes
Target IC₅₀: 1.41 µM against human arginine methyl transferase
Primary Target
human arginine methyl transferase
Product does not compete with ATP.
Reversible: no

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Novac, O., et al. 2004. Nucleic Acids Res.32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

light brown

DMSO: 200 mg/mL
methanol: soluble

ambient

2-8℃

25 mg in Plastic ampoule

11 - Combustible Solids

WGK 1