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Y-39983 dihydrochloride
产品别名
173897-44-4
Y-39983 dihydrochloride
4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-benzamide dihydrochloride
Y39983
Y 39983
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H16N4O · 2HCl |
| Molecular weight | 353.25 |
| MDL number | MFCD00945328 |
| Biochem/physiol Actions【生化/生理作用】 | Y-39983 is a potent and selective Rho-kinase (ROCK) inhibitor (IC50s = 3.6 nM). Y-39983 is 10 fold more potent in promoting the outgrowth of neurites in cultured retinal slices and axonal regeneration in crushed optic nerve models than Y-27632. Y-39983 act also as an activator of the neuroprotective Parkin-mediated mitophagy pathway. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D +5 to +9°, c = 1 in methanol |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | N[C@@H](C1=CC=C(C(NC2=CC=NC3=C2C=CN3)=O)C=C1)C.Cl.Cl |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
