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MEPB
产品别名
331948-99-3
MEPB
2-((2-phenoxyethyl)thio)-1-(2-(p-tolyloxy)ethyl)-1H-benzo[d]imidazole
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H24N2O2S |
| Molecular weight | 404.52 |
| Biochem/physiol Actions【生化/生理作用】 | MEPB is a modulator of the activation function-2 (AF-2) of the androgen receptor (AR), increasing AR co-repressor binding. MEPB specifically binds the BF3 pocket of the androgen receptor where it modulates binding of co-regulators to the AF2 domain. MEPB was found to rescue degeneration in a mouse model of spinal bulbar muscular atrophy, a motor neuron disease caused by toxic gain of function of the androgen receptor. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CC(C=C1)=CC=C1OCCN2C(SCCOC3=CC=CC=C3)=NC4=CC=CC=C42 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
