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Bis-Imidazole phenol IDH1 inhibitor
| 产品编号： | 4086621 |
| 规格： | ≥98% (HPLC), solubility: 30 mg/mL in DMSOclear |
| CAS NO： | 1648909-73-2 |
| 包装规格： | 25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
1648909-73-2
Bis-Imidazole phenol IDH1 inhibitor
2,6-Bis((1H-Imidazol-1-yl)methyl)-4-(2,4,4-trimethylpentan-2-yl)phenol
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H30N4O |
| Molecular weight | 366.50 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825871 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | bis-Imidazole phenol is a potent and cell permeable inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant R132H that inhibits D-2-hydroxyglutaric acid (2HG) production in cells. bis-Imidazole phenol binds to an IDH1 R132H allosteric site at the dimer interface containing residue involved in binding of the catalytically essential divalent cation. Bis-imidazole phenol blocks |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 30 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC1=C(CN2C=CN=C2)C=C(C(C)(CC(C)(C)C)C)C=C1CN3C=NC=C3 |
| InChI | 1S/C22H30N4O/c1-21(2,3)14-22(4,5)19-10-17(12-25-8-6-23-15-25)20(27)18(11-19)13-26-9-7-24-16-26/h6-11,15-16,27H,12-14H2,1-5H3 |
| InChI key | PCIJWPBOCDNTJF-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
