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AZD0530
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4086590 | 5 MG | 897 | 2-5天 | 4-6周 | |
| 4086590 | 10 MG | 3150 | 2-5天 | 4-6周 |
产品别名
379231-04-6
AZD0530
7-[2-[4-Methylpiperazin-1-yl]ethoxy]-5-[[tetrahydropyran-4-yl]oxy]-4-[[6-chloro-2,3-methylenedioxyphenyl]amino]quinazoline
4-(6-Chloro-2,3-methylenedioxyanilino)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-tetrahydropyran-4-yloxyquinazoline
AZD-0530
AZD 0530
N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
Saracatinib
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H32ClN5O5 |
| Molecular weight | 542.03 |
| MDL number | MFCD09832698 |
| Biochem/physiol Actions【生化/生理作用】 | AZD0530 is an orally active, potent tyrosine kinase inhibitor against Src family kinases (IC50 = 2.7 nM/c-Src, <4 nM/Lck, 4 nM/c-Yes, 5 nM/Lyn, 10 nM/Fyn, 10 nM/Fgr, 11 nM/Blk), v-Abl (IC50 = 30 nM) and EGFR (L861Q/L858R/wt IC50 = 4/5/66 nM). AZD0530 exhibits anti-proliferation activity in cancer cultures (IC50 = 80-700 nM; Src Y530F NIH 3T3, LoVo, K562, PC-9, SW 403, PC-3) and shows efficacy against several human tumor xenograft growth in mice in vivo (6.25-50 mg/kg/day p.o.; MDA-MB-231, AsPc-1, Calu-6, BT474C). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
