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Aftin-4
产品别名
866893-90-5
Aftin-4
Amyloid-β Forty-Two Inducer 4
(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
N6-Methyl-(R)-roscovitine
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H28N6O |
| Molecular weight | 368.48 |
| Biochem/physiol Actions【生化/生理作用】 | Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | protect from light |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 25 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
