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PF-06745268
产品别名
1812190-38-7
PF-06745268
2-[[(1aS,7bS)-1a,2-Dihydro-2,2-dimethyl-6-(trifluoromethyl)benzo[b]cyclopropa[d]pyran-7b(1H)-yl]methyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-2H-pyrido[1,2-a]pyrazine-1,6-dione
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H25F3N4O3 |
| Molecular weight | 498.50 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | PF-06745268 is an orally available, brain penetrant, potent and selective γ-secretase modulator. PF-06745268 induces robust and sustained reduction of brain amyloid-β42 (Aβ42) in rats. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc. Pfizer is a registered trademark of Pfizer, Inc. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D -13 to -17°, c = 1.0 in methanol |
| manufacturer/tradename | Pfizer® |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| originator【创始人】 | Pfizer |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1C(N2C=C(N=C2)C)=CC=C3N1CCN(C[C@@]4(C5)[C@@]5([H])C(C)(C)OC6=C4C=C(C(F)(F)F)C=C6)C3=O |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
