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NFAT Activation Inhibitor III-CAS 3519-82-2-Calbiochem
产品别名
3519-82-2
NFAT Activation Inhibitor III-CAS 3519-82-2-Calbiochem
Inhibitor of NFAT- Calcineurin Association-6, INCA-6
Inhibitor of NFAT-Calcineurin Association-6, INCA-6
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H12O2 |
| Molecular weight | 284.31 |
| General description【一般描述】 | A cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 µM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling. A cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Kd = 800 nM for calcineurin-NFAT Product does not compete with ATP. Reversible: no Primary Target Calcineurin-NFAT |
| Warning【警告】 | Toxicity: Carcinogenic / Teratogenic (D) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Roehrl, M.H.A., et al. 2004. Biochemistry43, 16067. Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA101, 7554. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 5 mg/mL (Use only fresh DMSO.) ethanol: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C20H12O2/c21-15-9-10-16(22)20-18-12-6-2-1-5-11(12)17(19(15)20)13-7-3-4-8-14(13)18/h1-10,17-18H |
| InChI key | GCHPUOHXXCNSQL-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
