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Protein Arginine N-Methyltransferase Inhibitor, AMI-1-Calbiochem
| 产品编号： | 4083945 |
| 规格： | The Protein Arginine N-Methyltransferase Inhibitor, AMI-1 controls the biological activity of Protein Arginine N-Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Protein Arginine N-Methyltransferase Inhibitor, AMI-1-Calbiochem
PRMT Inhibitor I
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H12N2Na4O9S2 |
| Molecular weight | 592.42 |
| General description【一般描述】 | A cell-permeable, symmetrical sulfonated urea compound that acts as a potent, specific and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC50 = 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC50 = 5 µM). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p Product does not compete with ATP. Reversible: no Primary Target Protein arginine N-methyltransferases (PRMTs) |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Cheng, D., et al. 2004. J. Biol. Chem.279, 23892. Skillman, A.G., et al. 2002. Bioorg. Chem.30, 443. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| solubility【溶解性】 | water: 50 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
