转化生长因子-βRI 激酶抑制剂 IV-CAS 909910-43-6-Calbiochem

C₂₅H₁₉N₅S

421.52

A cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC₅₀ = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.

Cell permeable: yes
Target IC₅₀: 45, 12, and 7.5 nM, respectively, in inhibit ALK-4/5/7-mediated luciferase transcription activity assays
Primary Target
ALK-4/5/7
Product does not compete with ATP.
Reversible: no

Toxicity: Harmful (C)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Tojo, M., et al. 2005. Cancer Sci.96, 791.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

200

≥97% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

pale yellow

DMSO: 20 mg/mL

ambient

2-8℃

2 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3