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InSolution ATM Kinase Inhibitor
| 产品编号： | 4080422 |
| 规格： | The InSolution |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H17NO3S2 |
| Molecular weight | 395.49 |
| General description【一般描述】 | A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 >100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118500) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). |
| Other Notes【其他说明】 | Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA102, 5056. Lau, A., et al. 2005. Nat. Cell Biol.7, 493. Hickson, I., et al. 2004. Cancer Res.64, 9152. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 2 mg in Glass bottle Packaged under inert gas |
