Hydroxyfasudil-CAS 155558-32-0-Calbiochem

C₁₄H₁₇N₃O₃S · xHCl

307.37 (free base basis)

A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC₅₀ = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.

Cell permeable: yes
Primary Target
Rho-kinase
Product competes with ATP.
Target IC₅₀: 0.9 and 1.8 µM against Rho-kinase using a peptide and MLC as substrate, respectively
Reversible: yes

Toxicity: Harmful (C)

A 10 mM (2 mg/582 µl) solution in H₂O.

Ito, K., et al. 2003. J. Physiol.546, 823.
Takemoto, M., et al. 2002. Circulation106, 57.
Shimokawa, H., et al. 1999. Cardiovasc. Res.43, 1029.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

liquid

Calbiochem^®

OK to freeze
protect from light

wet ice

−20℃

2 mg in Plastic ampoule
Packaged under inert gas

GHS07

Warning

H302

P264 - P270 - P301 + P312 - P501

Acute Tox. 4 Oral

11 - Combustible Solids

WGK 3