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Proteasome Inhibitor II-Calbiochem
| 产品编号： | 4073909 |
| 规格： | The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. |
| 包装规格： | 1 MG，5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Proteasome Inhibitor II-Calbiochem
(Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO
基本信息
| Empirical Formula【经验(实验)分子式】 | C29H39N3O5 |
| Molecular weight | 509.64 |
| General description【一般描述】 | A potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target MPC Product does not compete with ATP. Reversible: yes Target Ki: 460 nM against the pituitary multicatalytic proteinase complex (MPC) |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | Z-Leu-Leu-Phe-CHO |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months. |
| Other Notes【其他说明】 | Schauer, S.L., et al. 1998. J. Immunol. 160, 4398. Orlowski, M., et al. 1997. Biochemistry 36, 13946. Orlowski, M., et al. 1993. Biochemistry 32, 1563. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1, 5 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
