GSK-3β Inhibitor XII, TWS119-CAS 601514-19-6-Calbiochem

C₁₈H₁₄N₄O₂

318.33

MFCD09037535

A cell-permeable and potent inhibitor of GSK-3β (IC₅₀ = 30 nM). Binds to GSK-3β with high-affinity (K_d = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
A cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC₅₀ = 30 nM). Binds to GSK-3β with high-affinity (K_d = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).

Cell permeable: yes
Kd = 126 nM against GSK-3β
Product does not compete with ATP.
Reversible: no
Primary Target
GSK-3β

Toxicity: Carcinogenic / Teratogenic (D)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Ding, S., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7632.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

30 nM IC₅₀

Calbiochem^®

OK to freeze
protect from light

beige

methanol: 2 mg/mL
DMSO: 200 mg/mL

ambient

2-8℃

1, 5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3