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Protein C 来源于人类血浆
Protein C from human plasma
| 产品编号： | 4063636 |
| 规格： | Activated, lyophilized powder, ≥90% (SDS-PAGE) |
| CAS NO： | 42617-41-4 |
| 包装规格： | 0.1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
42617-41-4
Protein C 来源于人类血浆
Protein C from human plasma
Activated Protein C
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 3.4.21.69 ( BRENDA | IUBMB ) |
| MDL number | MFCD00165567 |
| NACRES | NA.61 |
| General description【一般描述】 | Protein C from human plasma is encoded by the gene PROC. In human chromosome, the gene is localised on chromosome 2q14. Activated protein C (APC) cleaves protease activated receptor 1 (PAR1) resulting in cytoprotective and anti-inflammatory effects. Clinical trials with APC implicates its use in treating severe early onset preeclampsia in pregnant women and prolongs pregnancy and helps in perinatal outcomes. |
| Application【应用】 | Protein C from human plasma has been used for pre-treatment of endothelial cells prior to antibody-inhibition assay. It has also been used in activated protein C (APC) assay to determine its inhibitory effect on copper. |
| Biochem/physiol Actions【生化/生理作用】 | Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa. In addition, activated protein C has been shown to inhibit TNF-α induced expression of the inflammatory proteins VCAM, ICAM-I, and Ilk-8 in endothelial cells. Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa. The Protein C anticoagulant pathway is triggered when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. This complex, which cannot clot blood, is a potent activator of the protein C zymogen. Activation involves the release of a dodecapeptide from the N-terminal domain of the heavy chain. The activated Protein C (APC) then binds to protein S on cell surfaces and inactivates the coagulation factors Va and VIIIa by proteolysis. APC has also been shown to bind to receptors on the endothelium of large blood vessels. |
| Physical form【外形】 | Lyophilized powder from 20 mM Tris-HCl, pH 7.4, containing 0.1 M NaCl |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human plasma |
| Assay【测定】 | ≥90% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| mol wt【分子量】 | heavy chain 41 kDa light chain 21 kDa |
| technique(s) | inhibition assay: suitable |
| solubility【溶解性】 | H2O: 1 mg/mL |
| UniProt accession no.【UniProt登记号】 | P04070 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PROC(5624) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
