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γ-Secretase Inhibitor IV-Calbiochem
| 产品编号： | 4063011 |
| 规格： | The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications. |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
γ-Secretase Inhibitor IV-Calbiochem
2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H26N2O3 |
| Molecular weight | 402.49 |
| General description【一般描述】 | A cell-permeable, reversible inhibitor of γ-secretase. Inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with Amyloid Precursor Protein Swedish mutants. A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants. |
| Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Primary Target Aβx-40 Reversible: yes Cell permeable: yes ED50 = 2.6 µM for Aβx-40 |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | 2-Naphthoyl-Val-Phe-CHO |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Green, K.N., et al. 2002. J. Physiol.541.3, 1013. Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
