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γ-Secretase Inhibitor I-Calbiochem
| 产品编号： | 4063010 |
| 规格： | The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications. |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
γ-Secretase Inhibitor I-Calbiochem
Z-LLNle-CHO
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H41N3O5 |
| Molecular weight | 475.62 |
| General description【一般描述】 | Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease. Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target γ-secretase Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | Z-Leu-Leu-Nle-CHO (Nle = Norleucine) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Skovronsky, D.M., et al. 2000. Biochemistry 39, 810. Hartmann, T., et al. 1997. Nat. Med. 3, 1016. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥90% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 10 mg/mL 50% acetic acid: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
