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CA-074-Calbiochem
| 产品编号： | 4061796 |
| 规格： | CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
CA-074-Calbiochem
Cathepsin B Inhibitor III, [L-3- trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H29N3O6 |
| Molecular weight | 383.44 |
| General description【一般描述】 | A potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC50 = 2.24 nM for rat liver cathepsin B). An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531). |
| Biochem/physiol Actions【生化/生理作用】 | Target IC50: 2.24 nM for rat liver cathepsin B Primary Target cathepsin B Product does not compete with ATP. Reversible: no Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Chan, V.J., et al. 1999. Biochem. J. 340, 113. Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187. Yamamoto, A., et al. 1997. J. Biochem.121, 974. Inubushi, T., et al. 1994. J. Biochem. 116, 282. Murata, M., et al. 1991. FEBS Lett. 280, 307. Towatari, T., et al. 1991. FEBS Lett. 280, 311. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | colorless to white |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
