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Anthrax Lethal Factor Protease Inhibitor, In-2-LF-Calbiochem
| 产品编号： | 4061783 |
| 规格： | The Anthrax Lethal Factor Protease Inhibitor, In-2-LF controls the biological activity of Anthrax Lethal Factor Protease. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anthrax Lethal Factor Protease Inhibitor, In-2-LF-Calbiochem
Anthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
基本信息
| Empirical Formula【经验(实验)分子式】 | C81H150N42O17 |
| Molecular weight | 1984.33 |
| General description【一般描述】 | A cell-permeable derivative of a 14-mer peptide that is based on the MEK-2 template and acts as a competitive inhibitor of Anthrax lethal factor metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Exhibits protective effects against Anthrax toxin-induced cytotoxicity in RAW264.7 and J772.A1 cells. Reported to competitively inhibit furin (Ki = 49 nM. A cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target anthrax LF metalloprotease Product does not compete with ATP. Cell permeable: yes Target Ki: 1 nM against Anthrax lethal factor (LF) metalloprotease Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | Ac-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun.321, 601. Tonello, F., et. al. 2002. Nature418, 386. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | white |
| solubility【溶解性】 | water: 1 mg/mL 5% acetic acid: 5 mg/mL DMSO: 5 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
