顺式-5,8,11,14,17-二十碳五烯酸 钠盐

CH₃(CH₂CH=CH)₅(CH₂)₃CO₂Na

324.43

MFCD00079184

24894631

NA.77

Eicosapentaenoic acid (EPA)/timnodonic acid is an omega-3 polyunsaturated fatty acid (PUFA). This long-chain fatty acid is mainly found in fish oil.

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt has been used:

• to study its effect on the pathology of lupus in drug-induced and spontaneous mouse models
• to pretreat mouse alveolar macrophages to study the effect/relationship between amiodarone and eicosapentaenoic acid (EPA) concerning the cytokine release
• to examine if pharmacological correction with EPA supplementation might restore autophagic flux and reduce renal lipotoxicity in mice

Eicosapentaenoic acid (EPA) possesses anti-hyperglycemic, anti-oxidant, anti-hyperlipidemic, and anti-inflammatory properties. It aids in improving vasoreactivity. EPA is capable of suppressing vascular smooth muscle proliferation. It ameliorates pulmonary hypertension by preventing Fyn kinase activity. EPA exhibits a beneficial effect on lipid metabolism. It is used to treat hypercholesterolemia and atherosclerosis.
5-脂氧合酶抑制剂；可减少血栓素 A2 的生成。

200

synthetic (organic)

≥99% (capillary GC)

film or powder

white to off-white

methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

dry ice

−20℃

[Na].CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

1S/C20H30O2.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;;/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22);;/b4-3-,7-6-,10-9-,13-12-,16-15-;;

TVEGTERCKGGVCJ-LIJGWLRISA-N

human ... ALOX5(240)
mouse ... ALOX5(11689)
rat ... ALOX5(25290)

13 - Non Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)