您的位置：首页 > 产品中心 > β-Secretase inhibitor
β-Secretase inhibitor
基本信息
| Empirical Formula【经验(实验)分子式】 | C73H118N16O27 |
| Molecular weight | 1651.81 |
| MDL number | MFCD02683580 |
| NACRES | NA.77 |
| Amino Acid Sequence | Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe |
| General description【一般描述】 | β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1), an aspartic protease belongs to the protease family of enzymes comprises of six luminal cysteine residues. These residues help in the formation of three intermolecular disulfide bonds and N-linked glycosylation sites. |
| Application【应用】 | β-Secretase inhibitor has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay.(2) β-Secretase inhibitor may be used to inhibit BACE1 in studies related to AD. |
| Biochem/physiol Actions【生化/生理作用】 | β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is a β-secretase that initiates the production of amyloid protein in Alzheimer′s dieases (AD) patients. β-Secretase inhibitors decrease the generation of β amyloid and formation of amyloid plaques typical of AD. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | synthetic (organic) |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| mol wt【分子量】 | ~_1.65 kDa |
| color【颜色】 | white |
| mp | 200 ℃ |
| solubility【溶解性】 | DMSO: soluble |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
