Anti-SHP2 (Y584) antibody produced in rabbit

NA.41

SHP2, also known as PTPN11, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in the gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

SHP2 (NP_002825, 563-596)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y584 of human SHP2.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

rabbit

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

human

indirect ELISA: 1:1000
western blot: 1:100-1:500

NP_002825

dry ice

−20℃

human ... SHP2(5781)

12 - Non Combustible Liquids

nwg