您的位置：首页 > 产品中心 > Anti-PRL1 antibody produced in rabbit
Anti-PRL1 antibody produced in rabbit
| 产品编号： | 3388444 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PRL1 antibody produced in rabbit
Anti-Tyrosine phosphatase
Protein tyrosine phosphatase type IVA(member 1)
Anti-PTP4A1 protein
Hypothetical protein DKFZp779M0721
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Protein-tyrosine-phosphatase of regenerating liver 1 (PRL1), also known as protein tyrosine phosphatase type IVA, member 1 (PTP4A1), is encoded by the gene mapped to human chromosome 6q12. The encoded protein is a member of a small class of prenylated protein tyrosine phosphatases (PTPs). It is characterized by a PTP domain and a specific C-terminal prenylation motif. PRL1 is mainly localized to the cell membrane and the endoplasmic reticulum depending on its C-terminal prenylation. |
| Immunogen【免疫原】 | PRL1 (NP_003454.1, 1-200) This antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL1. |
| Biochem/physiol Actions【生化/生理作用】 | Protein-tyrosine-phosphatase of regenerating liver 1 (PRL1) regulates cancer-related signaling pathways, which are downstream of epidermal growth factor receptor (EGFR) pathway and stimulates cell proliferation, invasion and migration. PRL1 acts as a potential therapeutic target and predictor for patient survival in prostate cancer (PCa) including those with castration-resistant prostate cancer (CRPC). PRL1 is essential for normal mitotic process. Elevated expressions of prenylated protein tyrosine phosphatases (PTPs) in mammalian cells conferred a transformed phenotype, which might be involved in the tumorigenesis. |
| Physical form【外形】 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | indirect ELISA: 1:1000 |
| NCBI accession no.【NCBI登记号】 | NP_003454.1 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PRL1(7803) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
