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Anti-MAP3K4 antibody produced in rabbit
产品别名
Anti-MAP3K4 antibody produced in rabbit
MAP3K4
M3K4
MAP three kinase 1
MAPK/ERK kinase kinase 4
KIAA0213
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | MAP3K4 (mitogen-activated protein kinase kinase kinase 4) gene encodes a component of protein kinase signal transduction cascade. It is also termed as MTK1 (MAP3 kinase 1). MAP3K4 contains a protein kinase catalytic domain at the C terminus and a regulatory/autoinhibitory domain at the N-terminus. It is located on human chromosome 6q26. Anti-MAP3K4 Antibody detects endogenous levels of total MAP3K4 protein. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human MAP3K4. Immunogen Range: 1281-1330 |
| Biochem/physiol Actions【生化/生理作用】 | MAP3K4 (mitogen-activated protein kinase kinase kinase 4) phosphorylates and activates a specific MAPK kinase (MAPKK) in the cascade through phosphorylation of conserved threonine and/or serine residues. GADD45 (growth arrest and DNA-damage-inducible proteins) proteins interact with and free the autoinhibitory domain from the kinase domain, thus activating MAP3K4. It mediates the activation of p38 MAPK pathway and the JNK (c-Jun N-terminal kinase) pathway induced by environmental stresses. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 181 kDa |
| species reactivity | human, mouse |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:5000 immunohistochemistry: 1:50-1:100 |
| NCBI accession no.【NCBI登记号】 | Q9Y6R4 |
| UniProt accession no.【UniProt登记号】 | Q9Y6R4 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MAP3K4(4216) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
