Anti-dcr-1 (center) antibody produced in rabbit

NA.41

The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III.
DCR-1 (dicer 1, ribonuclease III) is an RNase ΙΙΙ endoribonuclease. It is located on human chromosome 14q32.

DCR (NP_498761, 1008-1042)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of C. elegans Dcr-1.

Dcr-1 is required both for RNA interference and for the synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.
DCR-1 (dicer 1, ribonuclease III) has the ability to cleave dsRNA into smaller fragments that mediate RNAi. It plays an important role in miRNA processing and participates in innate immunity. DCR-1 is essential for the production of endo-siRNAs implicated in gene silencing and epigenetic modulation.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

rabbit

100

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

indirect ELISA: 1:1000

NP_498761

P34529

dry ice

−20℃

12 - Non Combustible Liquids

nwg