3-甲基-2-氧化吲哚

C₉H₉NO

147.17

MFCD04037370

24872867

NA.22

3-Methyl-2-oxindole (MOI) is a 3-substituted-2-oxindole. It is reported to be formed during the oxidation of indole-3-acetic acid in the presence of Fe^II under aerobic conditions. MOI undergoes asymmetric anti-Mannich-type reaction with N-tosyl aryl aldimines in the presence of alkaloid cinchona derivatives to form anti-3,3-disubsituted 2-oxindole derivatives. It also undergoes asymmetric hydroxyamination with nitrosoarenes to form N-nitroso aldol products.

3-Methyl-2-oxindole may be used in the preparation of 3-hydroxy-3-methyl-2-oxindole.

• Reactant for enantioselective α-amination reactions
• Reactant for aldol reaction with glyoxal derivatives
• Reactant for amine thiourea catalyzed conjugate addition to α,β-unsaturated aldehydes
• Reactant for O-acetylation reactions
• Reactant for preparation of a disubstituted oxoindole by using rhodium-catalyzed cyclopropanation/ring-opening reactions

100

96%

117-121 ℃ (lit.)

CC1C(=O)Nc2ccccc12

1S/C9H9NO/c1-6-7-4-2-3-5-8(7)10-9(6)11/h2-6H,1H3,(H,10,11)

BBZCPUCZKLTAJQ-UHFFFAOYSA-N

5, 25 g in glass bottle

13 - Non Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)