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3-Ethoxy-5,6-dibromosalicylaldehyde
产品别名
20041-64-9
3-Ethoxy-5,6-dibromosalicylaldehyde
5,6-Dibromo-o-bourbonal
2,3-Dibromo-5-ethoxy-6-hydroxy-benzaldehyde
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C9H8Br2O3 |
| Molecular weight | 323.97 |
| MDL number | MFCD00297095 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825197 |
| NACRES | NA.77 |
| Application【应用】 | 3-Ethoxy-5,6-dibromosalicylaldehyde was used to study modulation of autophagy, JNK activation and NF-κB-mediated inflammation. |
| Biochem/physiol Actions【生化/生理作用】 | 3-Ethoxy-5,6-dibromosalicylaldehyde is a non-competitive inhibitor of Inositol-requiring enzyme 1 (IRE1). It inhibits XBP-1 splicing induced pharmacologically in human cells. 3-Ethoxy-5,6-dibromosalicylaldehyde potently inhibits the endoribonuclease of IRE1 but does not inhibit RNases A, T1, or L. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: ≥15 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CCOc1cc(Br)c(Br)c(C=O)c1O |
| InChI | 1S/C9H8Br2O3/c1-2-14-7-3-6(10)8(11)5(4-12)9(7)13/h3-4,13H,2H2,1H3 |
| InChI key | MZAISYPWQNBWED-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H317 |
| Precautionary Statements | P280 - P301 + P312 + P330 - P302 + P352 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Skin Sens. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
